Oral itraconazole is an antifungal that has been shown to be of benefit to patients with allergic bronchopulmonary aspergillus (ABPA). It is hypothesized that itraconazole may similarly benefit patients with allergic fungal sinusitis (AFS), a disease similar to ABPA. This study was designed to evaluate the therapeutic response. The role of itraconazole in recalcitrant fungal sinusitis. Kristin Seibierling, M.D., and Peter-John Wormald, M.D., F.R.A.C.S.. ABSTRACT. Background: Oral itraconazole is an antifungal that has been shown to be of beneﬁt to patients with allergic bronchopulmonary aspergillus (ABPA). It is hypothesized that itraconazole may.
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Changes clinical practice - In patients with allergic fungal sinusitis (AFS) and non-allergic fungal eosinophilic sinusitis (NAFES) who have recurrent disease after multiple surgeries and courses of oral steroids, treatment with itraconazole for months is recommended. The discussion with the patient should include. preoperative itraconazole in allergic fungal rhinosinusitis. Am. J. Rhinol. Allergy 29, –. Seiberling, K.; Wormald, P. J. The role of itraconazole in recalcitrant fungal sinusitis. Am. J. Rhinol. Allergy , 23, – Rains, B. M.; Mineck, C. W. Treatment of allergic fungal sinusitis with high-dose itraconazole.
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